dnareplicationforkstalling

,由CMKondratick著作·2021·被引用39次—Prolongedstallingofreplicationincellsleadstoforkcollapse,whichinvolvesdisassemblyofthereplisome,forkreversaland/orbreakagegeneratingDNA ...,由HLiao著作·2018·被引用174次—StalledreplicationforksarecharacterizedbyextensivessDNA,generatedbypolymerase–helicaseuncouplingornucleolyticprocessing25,26,whichisvery ...,由JLAlexander著作·2016·被引用107次—Obstructionstor...

參考資訊如下
DNA replication stress

Making choices

由 CM Kondratick 著作 · 2021 · 被引用 39 次 — Prolonged stalling of replication in cells leads to fork collapse, which involves disassembly of the replisome, fork reversal and/or breakage generating DNA ...

Mechanisms for stalled replication fork stabilization

由 H Liao 著作 · 2018 · 被引用 174 次 — Stalled replication forks are characterized by extensive ssDNA, generated by polymerase–helicase uncoupling or nucleolytic processing 25, 26, which is very ...

Replication fork instability and the consequences of ...

由 JL Alexander 著作 · 2016 · 被引用 107 次 — Obstructions to replication fork progression cause fork stalling and increase the likelihood of fork collapse and breakage. Although stalled forks can resume ...

Replication Fork Reversal and Protection

由 S Qiu 著作 · 2021 · 被引用 32 次 — They are recruited to the stalled replication forks by interactions with other proteins, like RPA or PCNA, and then bind DNA sequences via ...

Replication Fork Stalling and the Fork Protection Complex

Two main activities happen at the fork: DNA unwinding and DNA synthesis. The RF unwinds the unreplicated DNA ahead of it through a helicase enzyme complex ( ...

Replication fork stalling elicits chromatin compaction for the ...

由 G Feng 著作 · 2019 · 被引用 21 次 — DNA replication forks in eukaryotic cells stall at a variety of replication barriers. Stalling forks require strict cellular regulations to ...

Stalled DNA Replication Fork

However, prolonged RF stalling leads to DNA damage; alternatively, the fork may collapse if Rad53 (Cds1 in fission yeast, or Chk1 in metazoa) is absent, and ...